SYBYL is a general molecular modelling program written by Tripos. SYBYL is a comprehensive computational tool kit for molecular design and analysis, with a special focus on the creation of new chemical entities. SYBYL provides essential construction and analysis tools for both organic and inorganic molecular structures, and much, much more.

SYBYL/Base gives you access to building tools, molecular mechanics, quantum mechanical calculations, molecular dynamics, docking, geometric measurements, molecular comparisons (fits), surfaces and grid displays, journaling, annotation, hard copy, a programming language, an object manager, and the Molecular Spreadsheet; all are included in the core module. Large and small molecules are modeled in the same window, with no special tricks or separate setups. No other company gives you this much in a core product.

SYBYL is a modular program. Researchers can take advantage of as much of the specialized tools as necessary by adding functionality focused on conformational searching (AdvComp), biopolymer modeling (Biopolymer), combinatorial chemistry or library design (Legion, Selector, DiverseSolutions), quantitative structure activity statistics (QSAR and TOPKAT, Advanced CoMFA), protein homology modeling and analysis (Composer, MatchMaker, ProTable), pharmacophore recognition (RECEPTOR, DISCO), and others. SYBYL also connects seamlessly to UNITY, Tripos' Chemical Database Searching system.

See also http://www.ch.cam.ac.uk/SGTL/Tripos/Sybyl.html