Non-linear regression programs for the Macintosh and IBM PC. Weighted non-linear regression, simulations, Bayesian analysis, and Iteratively Reweighed Least Squares analyses are possible. In MultiForte models are specified by modifying model definition subroutines in FORTRAN. In Boomer the model is defined by the selection of parameters such as dose, first-order rate constant, volume etc. Integrated and differential equation type models are possible. Fitting algorithms include Gauss-Newton, Marquardt, and simplex. Numerical integration routines include Runge-Kutta, Runge-Kutta-Fehlberg, and Gears.
Hardware: Macintosh and IBM PC.
Cost:40 dollars for Mac version.
Simulation software written for the Apple II computer. Students select model type, input plot descriptions input parameter values and the computer presents a linear or semi-log plot of the calculated values. With appropriate printer hard copy is available. Written in AppleSoft BASIC. Models include one or two compartment pharmacokinetic models, single and mutiple dose. Only integrated equation models are included in the Apple II version.
Hardware: Apple IIe being ported to the Macintosh (68020+).
Cost: Distribution Only.
Workshops to compliment pharmacokinetics undergraduate course self assesment style.
Hardware: BBC Software.
Cost: 50 pounds.
Powerful but very friendly pharmacokinetic modeling program. Models 2 different pharmacokinetic situations including linear and non linear elimination. Sample tutorial and demonstration disc available.
Hardware: IBM compatable PC.
Cost 200 pounds.
Dr P H Rowe
Pharmacokinetics simulation
Hardware: IBM-compatable PC
Cost: 70 pounds.
Gabrielsson
Simulation program in Pharmacokinetics
Hardware: IBM-compatable PC.
Cost: 100 pounds approx.
IRL Press
Computer simulation of pharmacokinetics which enables patient factors and drug factors to be changed. Changes are reflected in drug concs. in biological fluids.
Hardware: Mainframe computer.
Dr D Ingram
Non-linear regression programs for the VAX/VMS, DOS, or SUN/UNIX. Models are specified using FORTRAN statements. Requires a FORTRAN compiler as each model is recompiled before use. Simulation can be error free of with noise or based on population values. Uses the LSODA method for numerical integration (which is suitable for non- stiff and stiff problems). The program will perform simplex optimization, maximum likelihood and Bayesian fitting or will develop optimal sampling designs.
Hardware: VAX/VMS, DOS, or SUN/UNIX.
Cost: Free (in U.S.)
David Z. D'Argenio
Computer prgram for fitting nonlinear mixed effects (statistical regression-type) models. These techniques are particularly useful where the data are population pharmacokinetic data and when there are few measurements from each subject and/or the variation between subjects is considerable.
Hardware: Computer capable of compiling FORTRAN77 code, but workstation, mainframe recommended. Cost: Academic US$150.
Dr Stuart Beal
Computer programs for performing non- linear regression analysis. Models are specified by means of various parameters or free-form equations. SAAM30 is operated in batch mode while CONSAM is more interactive. Numerical integration routines are available non-stiff and stiff systems.
Hardware: VAX/VMS and DOS.
Cost: Free (in U.S.).
Loren A. Zech, M.D.
CAL porgrams in pharmacokinetics
Hardware: (1) BBC (2) IBM-compatable PC.
Alan Kensley