The book entitiled
"Pharmacophore Perception, Development, and Use in Drug Design"
has been released. It should appear in Barnes & Noble and Amazon
sites shortly. Meanwhile you can contact the publisher for a copy at
info@iul-press.com.
Below is the Table of Contents...
Preface
O.F.Guner
Part I: The Origins of Pharmacophore
Research
1. Evolution of the Pharmacophore
Concept in Pharmaceutical Research
P.Gund
Part II: Analog-Based
Pharmacophores
2. Manual Pharmacophore Generation:
Visual Pattern Recognition
O.F.Guner
3. Pharmacophore Definition Using the
Active Analog Approach D.D.Beusen,
G.R.Marshall
Automated Pharmacophore Development
Systems
4. DISCO: What We Did Right and What
We Missed Y.C.Martin
5. HipHop: Pharmacophores Based on
Multiple Common-Feature Alignments
O.A.Clement, A.T.Mehl
6. GASP: Genetic Algorithm Superposition
Program G.Jones, P.Willett,
R.C.Glen
7. Exploring Pharmacophores with Chem-X
S.J.Cato
Predictive Model Development - 3D
QSAR
8. Apex-3D: Activity Prediction
Expert System with 3D QSAR E.R.Vorpagel,
V.E.Golander
9. Pharmacophore Models and Comparative
Molecular Field Analysis (CoMFA)
R.D.Clark, J.M.Leonard, A.Strizhev
10. HypoGen: An Automated System for
Generating Predictive 3D Pharmacophore Models
H.Li, J.M.Sutter, R.Hoffmann
Applications in Drug Design
11. Metric for Analyzing Hit Lists
and Pharmacophores O.F.Guner,
D.R.Henry
12. Strategies in Database Mining and
Pharmacophore Development O.F.Guner,
M.Waldman,
R.Hoffmann, J-H.Kim
13. Pharmacophore Modeling by Automated
Methods: Possibilities and Limitations
M.Langgard, B.Bjornholm,
K.Gundertofte
14.Database Mining Using Pharmacophore Models to Discover Novel Structural
Prototypes J.J.Kaminski, D.F.Rane,
M.L.Rothofsky
15. Predicting
Drug-Drug Interactions in
Silico using Pharmacophores: A Paradigm
for the Next Millenium S.Ekins, B.J.Ring,
G.Bravi, J.H.Wikel, S.A.Wrighton
16. Feature-Based Pharmacophores: Applications to Some Biological Systems
R.Hoffmann, H.Li, T.Langer
17. The Design and Pharmacophore
Definition of Retinoid-X-Receptor Specific Ligands
S.K.White
Part III: Receptor-Based
Pharmacophores
18. Receptor-based Pharmacophore
Perception and Modeling
C.M.Venkatachalam, P.Kirchhoff,
M.Waldman
19. Pharmacophore-Based Molecular
Docking B.E.ThomasIV, D.Joseph-McCarthy,
J.C.Alvarez
Applications in Drug Design
20. The Use of Multiple Excluded
Volumes Derived from X-Ray Crystallographic Structures in 3D Database
Searching and 3D-QSAR M.Gillner,
P.Greenidge
21. Docking-Derived Pharmacophores from
Models of Receptor-Ligand Complexes
R.Griffith, J.B.Bremner, B.Coban
22. Technique for Developing a
Pharmacophore Model That Accommodates Inherent Protein Flexibility: An
Application to HIV-1 Integrase
K.M.Masukawa, H.A.Carlson,
J.A.McCammon
Part IV: New Algorithms in
Pharmacophore Development
23. Pharmacophores Derived from the 3D
Substructure Perception S.Handshuh,
J.Gasteiger
24. The Electron-Conformational Method
of Identification of Pharmacophore and Anti-Pharmacophore Shielding
I.B.Bersuker, S.Bahceci,
J.E.Boggs
25. Development and Optimization of
Property-Based Pharmacophores
A.G.Ozkabak, M.A.Miller, D.R.Henry,
O.F.Guner
26. Effect of Variable Weights and
Tolerances on Predictive Model Generation
J.M.Sutter, O.F.Guner, R.Hoffmann,
M.Waldman
Part V: The Future of Pharmacophore
Research
27. Future Directions in Pharmacophore
Discovery J.H.VanDrie
Osman F. Guner, Ph.D..