This book presents in one volume a sequence of chapters leading from classical methods through today's newest state-of-the-art technology for oligosaccharide synthesis. It places particular emphasis on the most recent breakthroughs in the field, including emerging technologies for both oligosaccharide and glycoconjugate synthesis. Chapters describing the synthesis of the increasingly important glycosidic linkage analogs, as well as of oligosaccharides containing derivatives and analogs of natural sugars are included. Enzymatic synthesis, also covering combined chemical and enzymatic synthesis, is also included. Chapters are written by the leading experts in the field. Wherever possible, methods of synthesis are provided in sufficient detail to allow the reader to implement the techniques described. More than 1700 references are provided in the 21 chapters comprising the book. This volume should provide a wealth of information to a large number of synthetic organic chemists, medicinal chemists, protein chemists, biochemists, glycobiologists and cell biologists, including students in these fields.

Harwood Academic Publishers
ISBN: 3-7186-5785-6 (Cloth)
ISBN: 3-7186-5921-2 (Paperback)

Further information about this publication can be obtained from: mailto:info@gbpub.com
utpbooks@gpu.utcc.utoranto.ca

http://www.twics.com/~gbtokyo/home.html
http://www.titlenet.com/GB/

TABLE OF CONTENTS AND CONTRIBUTORS

Foreword
Raymond U. Lemieux

1. Twenty Five Years of Carbohydrate Chemistry; An Overview of Oligosaccharide Synthesis
   Hans Paulsen
2. The Anomeric O-Alkylation and the Trichloroacetimidate Method - Versatile Strategies for Glycoside Bond Formation
   Richard R. Schmidt
3. Synthesis of Glycosyl Halides for Oligosaccharide Synthesis Using Dihalogenomethyl Methyl Ethers
   Pavol Kovac
4. Glycosylation Properties and Reactivity of Thioglycosides, Sulfoxides, and other S-glycosides: Current Scope and Future Prospects
   Thomas Norberg
5. Phenyl Selenoglycosides as Versatile Glycosylating Agents in Oligosaccharide Synthesis and the Chemical Synthesis of Disaccharides Containing Sulfur and Selenium
   Seema Mehta and B. Mario Pinto
6. Synthesis and Use of S-Xanthates, Carbohydrate Enol-Ethers and Related Derivatives in the Field of Glycosylation
   Pierre Sina and Jean-Maurice Mallet
7. n-Pentenyl Glycosides in Oligosaccharide Synthesis
   Robert Madsen and Bert Fraser-Reid
8. Coupling of Glycals: A New Strategy for the Rapid Assembly of Oligosaccharides
   Mark T. Bilodeau and Samuel J. Danishefsky
9. Advances in Polymer-Supported Solution Synthesis of Oligosaccharides
   Jiri J. Krepinsky
10. Protecting Groups in Oligosaccharide Synthesis
    T. Bruce Grindley
11. Synthesis of beta-D-Mannose Containing Oligosaccharides
    Frank Barresi and Ole Hindsgaul
12. Synthesis of Sialoglycoconjugates
    Akira Hasegawa
13. Synthetic Studies on Cell-Surface Glycans: An Approach to O-linked Sialoglycoprotein
    Yoshiaki Nakahara, Hiroyuki Iijima and Tomoya Ogawa
14. Synthesis of C-Glycosides; Stable Mimics of O-Glycosidic Linkages
    Carolyn R. Bertozzi and Mark Bednarski
15. Recent Developments in Glycopeptide Synthesis
    Stefan Peters, Morten Meldal and Klaus Bock
16. Design and Synthesis of Glycoconjugates
    Ren Roy
17. Synthesis of Biologically Active Sulfated and Phosphorylated Oligosaccharides
    Wasimul Haque and Robert M. Ippolito
18. Synthetic Glycosyltransferase Acceptors and Inhibitors; Useful Tools in Glycobiology
    Khushi L. Matta
19. Practical Synthesis of Oligosaccharides Based on Glycosyltransferases and Glycosylphosphites
    Chi-Huey Wong
20. Use of Glycosyltransferases in the Synthesis of Unnatural Oligosaccharide Analogues
    Suzanne C. Crawley and Monica M. Palcic
21. Synthesis with Glycosidases
    Kurt G. I. Nilsson